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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Tannic acid, Cisplatin
Phytochemical Name Tannic acid (PubChem CID: 16129778 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 523
Ref_1
Pair Name Tannic acid, Cisplatin
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Biological Phenomena Induction-->Mitochondria-mediated apoptosis
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Cleavage CASP3 hsa836
Up-regulation Expression CYCS hsa54205
In Vitro Model Hep-G2 Hepatoblastoma Homo sapiens (Human) CVCL_0027
Result The results obtained from the present study suggest that the combination of TA and CDDP may exert synergistic anticancer effects and may be a novel adjuvant treatment for liver cancer.
Combination Pair ID: 894
Ref_2
Pair Name Tannic acid, Cisplatin
Disease Info [ICD-11: 2C25] Lung cancer Investigative
Biological Phenomena Induction-->Endoplasmic reticulum stress
Gene Regulation Up-regulation Expression ATF4 hsa468
Up-regulation Expression ATF6 hsa22926
Up-regulation Cleavage CASP3 hsa836
Up-regulation Expression DDIT3 hsa1649
Up-regulation Expression EIF2AK3 hsa9451
Up-regulation Expression EIF2S1 hsa1965
Up-regulation Expression HSPA5 hsa3309
In Vitro Model NCI-H1299 Lung large cell carcinoma Homo sapiens (Human) CVCL_0060
GLC-82 Human papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_3371
In Vivo Model Cells (1×10⁷) were suspended in 200 µL 0.9% saline and injected subcutaneously into the axilla of 6-week-old mice for 7 d.
Result The combination of TA and CDDP may produce synergistic antitumoral effects mediated by the PERK-ATF4-CHOP apoptotic axis, suggesting a novel adjuvant treatment for lung cancer.
Combination Pair ID: 895
Ref_3
Pair Name Tannic acid, Cisplatin
Disease Info [ICD-11: 2C25] Lung cancer Investigative
Biological Phenomena Induction-->Endoplasmic reticulum stress
In Vitro Model A-549 Lung adenocarcinoma Homo sapiens (Human) CVCL_0023
RAW 264.7 Leukemia Mus musculus (Mouse) CVCL_0493
In Vivo Model Mice were subcutaneously inoculated with LLC cells (1×10⁶/mouse) in 0.1 ml of PBS at the armpit of the foreleg.
Result Tannins in Phyllanthus emblica L. improves cisplatin efficacy in lung cancer cells by boosting endoplasmic reticulum stress to trigger immunogenic cell death
03. Reference
No. Title Href
1 Tannic acid synergistically enhances the anticancer efficacy of cisplatin on liver cancer cells through mitochondria‑mediated apoptosis. Oncol Rep. 2019 Nov;42(5):2108-2116. doi: 10.3892/or.2019.7281. Click
2 Synergistic anticancer activity of cisplatin combined with tannic acid enhances apoptosis in lung cancer through the PERK-ATF4 pathway. Eur J Med Res. 2023 Oct 27;28(1):462. doi: 10.1186/s40001-023-01420-z. Click
3 Tannins in Phyllanthus emblica L. improves cisplatin efficacy in lung cancer cells by boosting endoplasmic reticulum stress to trigger immunogenic cell death. Phytomedicine. 2024 Jan;123:155219. doi: 10.1016/j.phymed.2023.155219. Click
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