Pair Name	Tannic acid, Cisplatin
Disease Info	[ICD-11: 2C25.Z]	Lung cancer		Investigative
Biological Phenomena	Induction-->Endoplasmic reticulum stress
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
	RAW 264.7	Leukemia	Mus musculus (Mouse)	CVCL_0493
In Vivo Model	Mice were subcutaneously inoculated with LLC cells (1×10⁶/mouse) in 0.1 ml of PBS at the armpit of the foreleg.
Result	Tannins in Phyllanthus emblica L. improves cisplatin efficacy in lung cancer cells by boosting endoplasmic reticulum stress to trigger immunogenic cell death

Pair Name	Tannic acid, Cisplatin
Disease Info	[ICD-11: 2C25.Z]	Lung cancer		Investigative
Biological Phenomena	Induction-->Endoplasmic reticulum stress
Gene Regulation	Up-regulation	Expression	HSPA5	hsa3309
	Up-regulation	Expression	EIF2AK3	hsa9451
	Up-regulation	Expression	ATF4	hsa468
	Up-regulation	Expression	ATF6	hsa22926
	Up-regulation	Expression	DDIT3	hsa1649
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Expression	EIF2S1	hsa1965
In Vitro Model	NCI-H1299	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0060
	GLC-82	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_3371
In Vivo Model	Cells (1×10⁷) were suspended in 200 µL 0.9% saline and injected subcutaneously into the axilla of 6-week-old mice for 7 d.
Result	The combination of TA and CDDP may produce synergistic antitumoral effects mediated by the PERK-ATF4-CHOP apoptotic axis, suggesting a novel adjuvant treatment for lung cancer.

Pair Name	Tannic acid, Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Mitochondria-mediated apoptosis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Expression	CYCS	hsa54205
	Up-regulation	Cleavage	CASP3	hsa836
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
Result	The results obtained from the present study suggest that the combination of TA and CDDP may exert synergistic anticancer effects and may be a novel adjuvant treatment for liver cancer.